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Friday, August 2, 2013

UPCI researchers target 'cell sleep' to lower chances of cancer recurrence

Public release date: 1-Aug-2013
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Contact: Allison Hydzik
hydzikam@upmc.edu
412-647-9975
University of Pittsburgh Schools of the Health Sciences

PITTSBURGH, Aug. 1, 2013 An international research team led by University of Pittsburgh Cancer Institute (UPCI) scientists discovered that by preventing cancer cells from entering a state of cellular sleep, cancer drugs are more effective, and there is a lower chance of cancer recurrence. The findings, which will be published in the August 15 issue of the journal Cancer Research and are available online, are the first to show that it is possible to therapeutically target cancer cells to keep them from entering a cellular state called quiescence, or "cell sleep." Quiescence can be a dangerous source of tumor recurrence because cancer drugs don't typically destroy quiescent cells.
"Successful cancer therapy often is hampered by tumor cell quiescence because these cells remain viable and are a reservoir for tumor progression," said Anette Duensing, M.D., assistant professor of pathology at UPCI. "By inhibiting a key regulator of quiescence, we are able to kill a larger fraction of cancer cells."
Dr. Duensing and her colleagues made the discovery while studying gastrointestinal stromal tumors (GISTs), which are uncommon tumors that begin in the walls of the gastrointestinal tract. According to the American Cancer Society, about 5,000 cases of GISTs occur each year in the United States with an estimated five-year survival rate of 45 percent in patients with advanced disease.
GISTs are caused by a single gene mutation, which means they can be successfully treated with the targeted therapy drug imatinib, known by the trade name Gleevec. Unlike traditional chemotherapy, which kills all rapidly dividing cells, targeted therapy stops cancer by interfering with specific molecules needed for tumor growth.
Unfortunately, GISTs rapidly develop resistance to the treatment and complete cancer remission using Gleevec is rare. A key regulator of the cancer cell sleep process is a protein complex called DREAM, which is named for the multiple proteins involved. Gleevec induces cell sleep using the DREAM complex, which means that the drug intrinsically limits its own effectiveness.
"When we disrupted the DREAM complex in the lab, we significantly increased cancer cell death using Gleevec," said Dr. Duensing. "This underscores the importance of the DREAM complex as a novel drug target worthy of preclinical and clinical investigations."
###

The study is a collaboration with the Dana-Farber Cancer Institute in Boston and the Catholic University in Leuven, Belgium. Additional co-authors of this study include Sergei Boichuk, M.D., Ph.D., Joshua A. Parry, B.S., Kathleen R. Makielski, M.S., Julianne L. Baron, B.S., James P. Zewe, B.S., Keith R. Mehalek, M.S., and Danushka S. Seneviratne, B.S., all of UPCI's Cancer Virology Program; James A. DeCaprio, M.D., and Larisa Litovchick, Ph.D., both of the Dana-Farber Cancer Institute; Patrick Schffski, M.D., M.P.H., Maria Debiec-Rychter, M.D., Ph.D., and Agnieszka Wozniak, Ph.D., all of the Catholic University of Leuven in Belgium; and Nina Korzeniewski, Ph.D., of the University of Heidelberg School of Medicine in Germany.
This research was supported by Research Scholar Grant RSG-08-092-01-CCG from the American Cancer Society, the GIST Cancer Research Fund, The Life Raft Group and a number of private donations.
About UPCI
As the only NCI-designated comprehensive cancer center in western Pennsylvania, UPCI is a recognized leader in providing innovative cancer prevention, detection, diagnosis, and treatment; bio-medical research; compassionate patient care and support; and community-based outreach services. UPCI, a partner with UPMC CancerCenter, investigators are world-renowned for their work in clinical and basic cancer research.
http://www.upmc.com/media

Contact: Allison Hydzik
Phone: 412-647-9975
E-mail: HydzikAM@upmc.edu
Contact: Jennifer Yates
Phone: 412-647-9966
E-mail: YatesJC@upmc.edu
[ | E-mail | Share ]
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

UPCI researchers target 'cell sleep' to lower chances of cancer recurrence Public release date: 1-Aug-2013
[ | E-mail | Share ]
Contact: Allison Hydzik
hydzikam@upmc.edu
412-647-9975
University of Pittsburgh Schools of the Health Sciences

PITTSBURGH, Aug. 1, 2013 An international research team led by University of Pittsburgh Cancer Institute (UPCI) scientists discovered that by preventing cancer cells from entering a state of cellular sleep, cancer drugs are more effective, and there is a lower chance of cancer recurrence. The findings, which will be published in the August 15 issue of the journal Cancer Research and are available online, are the first to show that it is possible to therapeutically target cancer cells to keep them from entering a cellular state called quiescence, or "cell sleep." Quiescence can be a dangerous source of tumor recurrence because cancer drugs don't typically destroy quiescent cells.
"Successful cancer therapy often is hampered by tumor cell quiescence because these cells remain viable and are a reservoir for tumor progression," said Anette Duensing, M.D., assistant professor of pathology at UPCI. "By inhibiting a key regulator of quiescence, we are able to kill a larger fraction of cancer cells."
Dr. Duensing and her colleagues made the discovery while studying gastrointestinal stromal tumors (GISTs), which are uncommon tumors that begin in the walls of the gastrointestinal tract. According to the American Cancer Society, about 5,000 cases of GISTs occur each year in the United States with an estimated five-year survival rate of 45 percent in patients with advanced disease.
GISTs are caused by a single gene mutation, which means they can be successfully treated with the targeted therapy drug imatinib, known by the trade name Gleevec. Unlike traditional chemotherapy, which kills all rapidly dividing cells, targeted therapy stops cancer by interfering with specific molecules needed for tumor growth.
Unfortunately, GISTs rapidly develop resistance to the treatment and complete cancer remission using Gleevec is rare. A key regulator of the cancer cell sleep process is a protein complex called DREAM, which is named for the multiple proteins involved. Gleevec induces cell sleep using the DREAM complex, which means that the drug intrinsically limits its own effectiveness.
"When we disrupted the DREAM complex in the lab, we significantly increased cancer cell death using Gleevec," said Dr. Duensing. "This underscores the importance of the DREAM complex as a novel drug target worthy of preclinical and clinical investigations."
###

The study is a collaboration with the Dana-Farber Cancer Institute in Boston and the Catholic University in Leuven, Belgium. Additional co-authors of this study include Sergei Boichuk, M.D., Ph.D., Joshua A. Parry, B.S., Kathleen R. Makielski, M.S., Julianne L. Baron, B.S., James P. Zewe, B.S., Keith R. Mehalek, M.S., and Danushka S. Seneviratne, B.S., all of UPCI's Cancer Virology Program; James A. DeCaprio, M.D., and Larisa Litovchick, Ph.D., both of the Dana-Farber Cancer Institute; Patrick Schffski, M.D., M.P.H., Maria Debiec-Rychter, M.D., Ph.D., and Agnieszka Wozniak, Ph.D., all of the Catholic University of Leuven in Belgium; and Nina Korzeniewski, Ph.D., of the University of Heidelberg School of Medicine in Germany.
This research was supported by Research Scholar Grant RSG-08-092-01-CCG from the American Cancer Society, the GIST Cancer Research Fund, The Life Raft Group and a number of private donations.
About UPCI
As the only NCI-designated comprehensive cancer center in western Pennsylvania, UPCI is a recognized leader in providing innovative cancer prevention, detection, diagnosis, and treatment; bio-medical research; compassionate patient care and support; and community-based outreach services. UPCI, a partner with UPMC CancerCenter, investigators are world-renowned for their work in clinical and basic cancer research.
http://www.upmc.com/media

Contact: Allison Hydzik
Phone: 412-647-9975
E-mail: HydzikAM@upmc.edu
Contact: Jennifer Yates
Phone: 412-647-9966
E-mail: YatesJC@upmc.edu
[ | E-mail | Share ]
?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-08/uops-urt080113.php
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Wednesday, May 22, 2013

The Next Xbox: Everything We Think We Know

We're finding out about the new Xbox on May 21st. But that doesn't mean we have no idea what's coming. Here's a rundown of everything we know, or think we know, about the next Xbox.

Tuesday, May 21, 2013

It's Official: Yahoo Is Buying Tumblr, Promises "Not to Screw It Up"

After rumors spread during the weekend, it's now official: Yahoo is buying Tumblr. Yahoo has announced the takeover, aptly enough, on Tumblr, explaining that it "promises not to screw it up." That's a reference, obviously, to the complete mess it's made of pretty much every other company it's ever bought. In that Tumblr post Marissa Mayer explains:

Tumblr is incredibly special and has a great thing going. We will operate Tumblr independently. David Karp will remain CEO. The product roadmap, their team, their wit and irreverence will all remain the same as will their mission to empower creators to make their best work and get it in front of the audience they deserve.

It is at least reassuring to hear that Mayer mindful of the fact that Tumblr is already a Good Thing that doesn't need interfering with too much. More comforting for the legions of Tumblr users will be David Karp's own announcement, in which he reassures everyone that the site "isn't turning purple." He continues:

Our headquarters isn?t moving. Our team isn?t changing. Our roadmap isn?t changing. And our mission ? to empower creators to make their best work and get it in front of the audience they deserve ? certainly isn?t changing.

So what can we expect from the takeover? Well, both parties seem fairly certain that it'll be more of the same, only better. In Karp's words, "simply, Tumblr gets better faster." Mayer is a little more wordy and corporate:

"Tumblr can deploy Yahoo!?s personalization technology and search infrastructure to help its users discover creators, bloggers, and content they?ll love... The two companies will also work together to create advertising opportunities that are seamless and enhance user experience."

Blah, blah, blah. We can, of course, also expect David Karp to become filthy, filthy rich. But that aside, we'll learn more in an announcement call at 9am EST. Check back then for more details.

Source: http://gizmodo.com/its-official-yahoo-is-buying-tumblr-508846808

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Sunday, May 19, 2013

Egypt police close Gaza border to protest kidnap

CAIRO (AP) ? Dozens of disgruntled border policemen forced the closure of Egypt's main crossing point into the Gaza Strip on Friday to protest the abduction of their colleagues by suspected militants, underscoring the lawlessness and crisis of authority in the country two years since the uprising that toppled Hosni Mubarak.

The police protest comes a day after masked gunmen ambushed two taxis at gunpoint outside the city of el-Arish, the capital of North Sinai governorate, fleeing with four border policemen working at the Rafah crossing, a riot policeman, and a military border guard. Officials have not identified a seventh captive.

The abduction is the first confirmed case in the peninsula.

In 2011, four policemen went missing and their vehicle was found torched on Feb. 4, 2011 in el-Arish city. In a recent TV interview aired on private TV network al-Balad, the wives of two of the missing men claim they were abducted by masked militants and smuggled into Gaza through underground tunnels. They claimed that the country's Interior Minister himself confirmed they are alive and in Gaza.

However, security officials told The Associated Press that the abduction theory has lost support since authorities have failed to establish communication with the abductors, more than two years after their disappearance. A military official says authorities consider the four missing.

At Rafah terminal, one of the protesting policemen said his group plans to keep the crossing closed until their colleagues are freed.

"We are not leaving until those men return. We want Sinai to be secure. We need more police and army. Sinai is under control of the jihadis. The state is absent," he said over the phone from the crossing. "We are not safe here. The police are afraid. Since the revolution until this minute, nothing has changed or improved."

He spoke on condition of anonymity for fear of reprisal.

Authorities say the kidnappers were reacting to the alleged torture of a militant serving a life sentence in prison, and are in contact with mediators to obtain the captives' release.

It is not clear what the kidnappers want, but a security official says the police officer accused of torturing the militant has been summoned for questioning while the imprisoned militants were reportedly transferred to another prison. The police chief of North Sinai governorate, Gen. Sameh Beshadi, was quoted by daily Al-Masry Al-Youm on Friday as saying that the kidnappers want the release of militants imprisoned over a 2011 attack on a police station.

The official spoke on condition of anonymity because they were not authorized to speak to the press.

Ahmed Abu-Sheta, the militant who claims he was tortured until he lost his eyesight, was convicted along with others for involvement in the police station attack that left four dead. One of the kidnappers, identified by security authorities as Kamal Allam, was also sentenced to death in absentia in the same case.

The brother of Abu-Sheta denied that his family has any connection to the abduction in an interview with private-owned daily Al-Watan.

Lawlessness in the Sinai has increased after the breakdown of country's formerly powerful security forces.

Islamic militants have stepped up attacks on police stations and security convoys. Bedouin tribal gangs are involved in smuggling and other criminal activity. A flow of weapons from Libya's 2011 civil war has emboldened armed groups.

The killing of 16 Egyptian soldiers in August last year at the hands of masked militants marked a turning point in the Sinai. The military conducted several anti-militant sweeps but no attackers have been publically identified.

Lawlessness in the Sinai is also linked to political discontent. Local tribes accuse the central government of discrimination, neglect, and police brutality.

Egypt's Islamist President Mohammed Morsi has presided over the military operations but has also signaled he prefers mediation. On Thursday, he called for the "protection of the lives" of both the "abducted and the kidnappers" and said that the solutions to Sinai's problems should not be through "abductions and terrorizing citizens."

------------------------------------

AP writer Ibrahim Barzak in Gaza contributed to this story. Ashraf Sweilam contributed to this report from southern Sinai.

Source: http://news.yahoo.com/egypt-police-close-gaza-border-protest-kidnap-094451774.html

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Monday, December 3, 2012

Egyptians fear decades of Muslim Brotherhood rule, warn Morsi is ...

AFP / Getty Images

An Egyptian man delivers a speech as protesters gather in Cairo's landmark Tahrir Square on Friday to protest against a decree by President Mohammed Morsi granting himself broad powers that shield his decisions from judicial review.

By Richard Engel, NBC News Chief Foreign Correspondent

News Analysis

TAHRIR SQUARE, CAIRO -- This was the place where the revolution began: the roundish square where Egyptians celebrated Mubarak's fall.

This is where they are shouting on bullhorns again, outraged because they say the Muslim Brotherhood has stolen the revolution and is railroading though a constitution that could lock in Muslim Brotherhood rule for 50 years, bringing more Islamic law. They cry -- not against Islam -- but that an extremist interpretation is being forced down their throats by a president who critics say is acting every part the tyrant. ?

This is also a warning, they claim, of what may happen across the Middle East. The era of the Muslim?Brotherhood appears to have arrived. President Obama has hailed the Brotherhood's President Mohammed Morsi as a pragmatist who helped end the Gaza crisis. Egyptians here think the Brotherhood has conned Washington, just like it conned them.

Christians, liberals left out as Islamists back Egypt's draft constitution

"President?Obama is supporting a terrorist," a man told me amid chants of "Leave! Leave!" in Tahrir Square and "Down, down with the rule of the Muslim Brotherhood's spiritual leader." Before, it was "Down, down with Mubarak."

Morsi's decree divides Egypt
Egypt was torn in half just over a week ago when Morsi made himself more powerful than Mubarak ever was, and the kings before him. Morsi declared himself above judicial oversight, his decisions final and unassailable. He made himself, according to critics, a new pharaoh on the Nile. Imagine if, after five months in office, an American president announced that he could pass any law he pleased regardless of Congress or the U.S. Supreme Court. Imagine if he said his decisions were final and inspired by God.

After issuing a decree making himself more powerful than the courts, Egyptian president Mohamed Morsi has sparked a wave of anger ? some of which is directed toward the United States. NBC's Richard Engel reports.

Morsi last night apologized for the power grab and said he didn't want the extra authorities, but that they were necessary for the good of the people and to safeguard the revolution. Dictators always say stuff like that. Burn down the village to save it.

At first Egyptians were shocked that Morsi would make such an obvious and, according to Egyptian judges, blatantly illegal move. It's clear now, as some analysts have long feared, that the brotherhood is making sure it doesn't lose power again by taking control of Egypt's constitution. The Brotherhood wants to write the rules of the game. Now they've done that too.

PhotoBlog: Dueling demonstrations in Cairo

Protected by the president's new-found supreme and unquestionable powers, Morsi ordered his Islamist allies to finish writing the constitution and get it on his desk by the end of this week. They did it, even though many independent legal experts, Christians and opposition politicians boycotted the drafting process. The Brotherhood called the new constitution "a jewel." Many Egyptians say it leaves too much room for the implementation of Shariah law. ?

The constitution also empowers the people and government with a duty to uphold moral values, a vague clause that could pave the way for vigilante morality police. The constitution barely mentions protecting women's rights. According to women who were originally involved in the drafting process, and who subsequently left because they felt they were being ignored, clauses specifically demanding that women be protected from violence and sex trafficking were dropped because Islamists feared it would conflict with their desire to allow child brides.

ANALYSIS: Crisis tests Egyptians' constitution

The constitution has long been the Muslim Brotherhood's lodestar and, in the past, they have been willing the kill for it. In 1954, not long after a group of 'free officers' carried out a coup against the British-backed monarchy, a Brotherhood assassin tried to kill President Gamal Abdel Nasser. Nasser, a leading free officer, favored a mostly secular, pro-military constitution. The Brotherhood, an Islamist group that supports the return of Arab and Islamic unity and the revival of ancient Muslim glory and Shariah laws, couldn't accept the new rules.

Ahmed Youssef / EPA

18 days of popular protest culminated in the downfall of Egyptian president Hosni Mubarak on Feb. 11, 2011.

The Brotherhood's assassination attempt failed. The gunman's eight bullets, fired while Nasser was giving a speech in Alexandria, all missed. The Brotherhood was banned. The group went underground, at times tolerated but more often repressed by Nasser's successors: presidents Mubarak and Anwar el-Sadat. When the revolts started against Mubarak, the Brotherhood saw that fate had given them another chance.

Muslim Brotherhood's calculated rise to power
Looking back now, it all seems so obvious, yet many Egyptians refused to see it coming. In fact, many of the secular revolutionaries backed the Brotherhood, arguing they were better allies than the hated military. The Brotherhood played its cards well.

The Brotherhood was late to join the anti-Mubarak revolts in 2011. When students and liberals initially occupied Tahrir Square, it looked like it might be a passing thing. The Brotherhood either didn't appreciate its significance, or wanted to wait to see who was winning.

I remember watching the Brothers march into the square. They arrived in a large group of perhaps five hundred. Nearly all were men. Many had beards. Most were dressed in poorly cut dark suits. They occupied a corner of Tahrir near a Kentucky Fried Chicken. They came with microphones and wood to build a platform. The other protesters in the square seemed happy to have the support of the new arrivals.

Egypt's Morsi, top judges compromise to defuse soaring tensions over decree

The protests continued to grow. Labor unions went on strike. The military enacted a coup against Mubarak. President Obama withdrew his support for Washington's long-time Arab friend. And Mubarak the president was no more.

The Brotherhood first said it wouldn't seek the new presidency at all. It promised to exist solely as an influential member of civil society. Back then, many Egyptians feared the Brotherhood. It was a semi-secret group. It had a small office in a Cairo apartment building with a sign on the door the size of an index card. Mubarak-era officials had often described the Brotherhood as a group of terrorists. One security official I know called the Brotherhood the most dangerous group in the world. But in the heady 1960s-like days after Mubarak's resignation, the Brotherhood's bad reputation only seemed to give the group more credibility. They'd been oppressed by the man. It was a new day. Everyone, it appeared, deserved a new beginning.

Tens of thousands of protesters gathered in Tahrir Square Friday to denounce Egypt's President Mohamed Morsi and the draft constitution his Islamic allies approved earlier in the day.

The Brotherhood went to work. It organized its considerable finances. It built a big new headquarters with far bigger signs on the doors. It sent its representatives around the world, especially to Washington, on a charm offensive. We've been oppressed, they claimed. We were slandered by a tyrant. We're not what you've heard. We can unite the Sunni world against Iran. We can help bring Israeli-Palestinian peace. There were many promises of a great future.

Even then, the Brotherhood's focus on the constitution was clear. The Brotherhood insisted the constitution be drafted only after a new president was elected. The military was overseeing a transition back then. The Brotherhood argued that the military couldn't be trusted to oversee the creation of such an important document. Many Egyptians agreed -- a decision some sorely regret today.

NBC's Ayman Mohyeldin discusses the current unrest in Egypt

Morsi won the election by a narrow margin and then five months into his term, made himself a dictator and ordered his Islamist friends to quickly finish the constitution. Morsi has said he'll drop his extraordinary powers as soon as the constitution is approved in a referendum in December. Islamists are convinced they'll be able to use their grassroots network of activists to win the referendum like they won the elections. Western diplomats tend to agree.

Yet the United States has remained mostly silent on all this, urging both sides to stay calm and work it out. Washington's policy seems to be that what's going on is simply democracy in progress as Egyptians learn to use their new rights.

But in Tahrir Square people seem convinced the Brotherhood isn't testing its fledgling wings. They say Morsi knows exactly what he's doing, Washington be warned.?

More world stories from NBC News:

Follow World News from NBCNews.com on Twitter and Facebook

Source: http://worldnews.nbcnews.com/_news/2012/12/01/15578733-egyptians-fear-decades-of-muslim-brotherhood-rule-warn-morsi-is-no-friend-to-us

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Santa Clarita foreclosure Update ? have you subscribed to this yet ...

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If you are a police office or a?civilian, you will benefit from our Real Estate updates and how to best protect yourself when buying, selling, or investing in real estate.

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Sunday, December 2, 2012

Trailers In Motorcycle Travel

Are you ready for your motorcycle travel? It is necessary that you should do the proper arrangement to make your journey safe and comfortable. You can use trailers to make your journey awesome. Trailers not only look great, also very helpful in your journey. Motorcycle travel trailers will be used to make your long distance easy because of its facilities. They are lightweight and reasonable. They make your journey comfortable. You can get so many camper products in the market.

Trailers for Motorcycle Travel ? Two most used camping trailers used are ?

Mini Mate ? With this camping trailer, there is no need to worry about the things such as tent, fly and poles. 15 cubic feet space is available in this mini mate camping trailer. This will be used to store camping gear. You can also sleep in this camping trailer. This mini mate can also store some bulky items. You will easily install the tent. It?s really very much useful in your motorcycle travel. The tongue weight of this trailer is about20 lbs. This trailer is very comfortable and needful. You can sleep in this trailer easily.

Roadman Camping Trailers- Roadman camper is one of the best options for the travelers. They give you so many facilities in your motorcycle travel. There is enough storage space in this camper. The width of this trailer is 38 inch and the storage space is 15 cubic feet. This is easy in installation and it takes less time.

Select one of them and make trip comfortable and safe. There are many other things that you should take in your journey. There are so many trailers available in the market. You can get more information about these camping trailers at the Internet. Their price is also given there.?
There are many organizers who offer so many facilities to the motorcycle travelers. Royal Bike Riders offer you the facilities that you needed in your journey. They make the proper arrangement of lodging. They have so many experts in this field. They will give you their advice to make your journey easy and safe. If needed, they also send their bike riders with you. This helps you a lot in your journey. If you want a long journey, they make perfect arrangements for you. They also offer motorcycle travel to different countries. So select Royal Bike Riders for your motorbike travel and make your journey unforgettable, safe and comfortable.

About the Author:
As Motorcycle tour enthusiast and Motorcycle adventurer, this is our main motto to provide memorable and lifetime holidays to our esteemed guest. We select route and trails very carefully that is still unexplored, preserved and hidden on map and we share our passion and adventure for Motorcycle trip and travel.

Source: http://www.articlesnatch.com/Article/Trailers-In-Motorcycle-Travel/4299206

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